Release rate and antimicrobial activity of gentamicin salts as coating for bone allografts
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منابع مشابه
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.
While the infection rate of orthopedic implants is low, the required treatment, which can involve six weeks of antibiotic therapy and two additional surgical operations, is life threatening and expensive, and thus motivates the development of a one-stage re-implantation procedure. Polyelectrolyte multilayers incorporating gentamicin were fabricated using the layer-by-layer deposition process fo...
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A degradable, poly (lactic-co-glycolic acid) (PLGA), gentamicin-loaded prophylactic coating for hydroxyapatite (HA)-coated cementless hip prostheses is developed with similar antibacterial efficacy as offered by gentamicin-loaded cements for fixing traditional, cemented prostheses in bone. We describe the development pathway, from in vitro investigation of antibiotic release and antibacterial p...
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The use of bone allografts is contraindicated in septic revision surgery due to the high risk of graft reinfection. Antibiotic release from the graft may solve the problem and these combinations can theoretically be used for prevention or even therapy of infection. The present study investigated whether amoxicillin, ciprofloxacin, and vancomycin alone or in combination with chitosan or alginate...
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Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles (SiO₂ NPs) can be used as elegant carriers for antibiotics to prolong their release. Our goal is...
متن کاملبررسی مقایسهای روند ترمیم دو نوع آلوگرافت استخوانی داخل غضروفی با یکدیگر و با آلوگرافتهای داخل غشایی همراه با آنتیژن زدایی دو گانه
Background & Aim: When comparing bone autograft and allograft, conditions like performing two surgeries at the same time in an individual, size limitations of autografts, bleeding etc. forced specialists to think about the possible substitution of autografts with the allograft. In this study considering the importance of the kind of the chosen bone for graft, its embryologic origin, its his...
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